Optimal Outcome in a Girl with Early Regressive Autism: Diagnostic Withdrawal and Normative Developmental Profile Following a Naturopathic Intervention
Preprint, Katia Dolle et al. Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by marked etiological and clinical heterogeneity. In recent years, there has been growing recognition of the need to investigate integrative approaches that consider its potential multisystem nature. From the perspective of complex systems theory, effective interventions should necessarily be multidimensional […]
Plasma amino acid profile as a biomarker of malate-aspartate shuttle overload in a hepatic glycolytic defect (PFKFB1): a pre/post supplementation case study
Background: it has been proposed that the hepatic glycolytic blockade associated with a hemizygous PFKFB1 variant (p.Ser159Thr) causes cytosolic NADH accumulation, with a secondary increase in demand on the malate-aspartate shuttle (MAS) — the principal mechanism for transferring reducing equivalents from the cytosol to the mitochondria in the hepatocyte. In the index case (companion report […]
Optimal outcome in early-onset regressive autism: functional remission documented in a context of limited diagnostic access following a naturopathic intervention [MKD-TEA-003]
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by high aetiological and clinical heterogeneity. In recent years, the need to investigate integrative approaches that account for its possible multisystemic nature has been increasingly recognised. From a complex systems perspective, effective interventions should be necessarily multidimensional and adaptive. Case presentation: A 3-year-old male participant […]
Functional Remission and Diagnostic Overshadowing in Early Regressive Autism: A Longitudinal Case Study Following a Naturopathic Intervention [MKD-TEA-002]
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by marked etiological and clinical heterogeneity. In recent years, there has been growing recognition of the need to investigate integrative approaches that consider its potential multisystem nature. From the perspective of complex systems theory, effective interventions should necessarily be multidimensional and adaptive. Case Presentation: An […]
Perceived impact on health and quality of life among mothers of children with ASD following a personalized health program: a retrospective observational study
Introduction: Mothers of children with autism spectrum disorder (ASD) experience sustained functional impairment across multiple life domains, including sleep, autonomy, health, and social participation. Despite growing evidence on caregiver burden in ASD, the impact of child-directed interventions on maternal quality of life has not been systematically documented. This study explores perceived functional changes in primary […]
Development and description of a naturopathic instrument for the assessment of health status indicators in caregiving mothers of children with ASD: rationale, structure and baseline health status indicators
Introduction: Mothers of children with autism spectrum disorder (ASD) experience sustained functional impairment that simultaneously affects all areas of daily life. Available instruments for assessing this impact, designed within the clinical-psychological framework, capture internal states such as stress or anxiety but fail to measure the mother’s functional capacity to sustain her own life. Naturopathy, through […]
The Katia Dolle Method (KDM): Conceptual Framework and Clinical Reasoning Architecture for Integrative Naturopathic Care in Neurodevelopmental Disorders
The Katia Dolle Method (KDM) is a hierarchical clinical decision framework developed within clinical naturopathy for multisystemic intervention in neurodevelopmental disorders, with primary application in autism spectrum disorder (ASD). Developed over more than twenty-five years of intensive clinical practice and applied to a population exceeding 1,000 users across 32 countries, the KDM integrates principles from […]
Refractory obsessive-compulsive disorder with possible neuroimmune substrate: clinical response to a personalised qEEG-guided naturopathic intervention
Background: Refractory obsessive-compulsive disorder (OCD) represents a major clinical challenge. We describe the case of a 34-year-old male (F.R.C.) with severe OCD (baseline Y-BOCS = 24/40), childhood onset, eleven years of partial pharmacological response and documented hypersensitivity to multiple psychotropic drugs. The baseline qEEG (T0, 02/10/2025) was consistent with PANDAS with OCD comorbidity and emotional […]
Optimization of the ketogenic metabolic bypass in a pediatric participant with a PFKFB1 defect and complex neurometabolic phenotype: a two-phase prospective case study
Background: PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1) is a bifunctional enzyme regulating hepatic glycolytic flux. No OMIM disease entity is currently associated with PFKFB1 variants, and the clinical literature is virtually nonexistent. We describe the first prospective interventional case study in a participant carrying a hemizygous PFKFB1 variant (p.Ser159Thr, ChrX:54984780A>T). Case: A 14-year-old male with myoclonic epilepsy, a […]
Functional Remission and Diagnostic Shift in Autism Spectrum Disorder: Effectiveness of a Naturopathic Intervention in a Single Case
This report presents a longitudinal single-case study of a child with autism spectrum disorder (ASD) undergoing a multimodal naturopathic intervention based on the Katia Dolle Method® (KDM). The intervention was designed within a complex systems framework, targeting interconnected biological factors including intestinal dysbiosis, food hypersensitivity, micronutrient imbalances, and heavy metal burden. The case involves a […]
Reducing the severity of ASD with the Katia Dolle Method®: a retrospective cross-sectional study.
This retrospective cross-sectional study evaluates the effectiveness of the Katia Dolle Method® in reducing the severity of Autism Spectrum Disorder (ASD) in 183 children. The analysis was based on pre- and post-intervention ATEC scores collected between 2017 and 2024. Results show a highly significant reduction in ATEC scores (mean reduction: 39.20 points; p < 0.001), […]
Personalized naturopathic intervention in autism spectrum disorder with obsessive comorbidity: a case study from the perspective of complexity theory and qEEG analysis
Abstract This case report describes an 8-year-old boy with autism spectrum disorder (ASD) and obsessive comorbidity who underwent a four-month personalized naturopathic intervention. The intervention targeted multiple pathophysiological axes simultaneously, including hypothalamic–pituitary–adrenal (HPA) axis regulation, sleep disturbances, cerebral blood perfusion, neuroinflammation, cognition, and mental/emotional regulation. Clinical outcomes were qualitatively assessed through reports of profound changes […]
Katia Dolle Method® in ASD: Single Case Study — Case 001 [MKD-ASD-001], Phase 1 (21 months); A–B follow-up; Mexico, 2023–2024
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by difficulties in communication, social interaction, and repetitive behaviors. Considering its multifactorial origin and multisystem involvement, this single-case report applies a complex naturopathic intervention—the Katia Dolle Method® (KDM)—integrating immunonutrition, targeted supplementation, parental coaching, structured neurostimulation, and periodic biological monitoring over 21 months. A 4-year-old girl diagnosed with moderate–severe […]