Katia Dolle: investigación y publicaciones científicas
En esta página reúno la investigación de Katia Dolle y de la Fundación Katia Dolle: todos nuestros preprints y estudios, con acceso directo a cada publicación.
Investigación de Katia Dolle
En esta página reúno la investigación de Katia Dolle y de la Fundación Katia Dolle: todos nuestros preprints y estudios, con acceso directo a cada publicación.
Soy naturópata colegiada (FENACO nº 3449) y MSc, con más de 17 años de práctica clínica en neurodesarrollo. Dirijo el Comité Científico Asesor de la Fundación Katia Dolle y soy miembro del Comité Científico de OCN FENACO. [Conoce mi trayectoria →]
Qué encontrarás aquí
Los trabajos están publicados como preprints en acceso abierto, en Zenodo, cada uno con su DOI. Un preprint es un trabajo científico que se comparte antes de la revisión por pares, para que los datos sean públicos y verificables desde el primer momento. Estamos llevando estos trabajos a revistas científicas con revisión por pares; cuando se publiquen, los verás con la etiqueta «Artículo revisado por pares».
Son estudios observacionales y casos clínicos que describen la evolución de las familias que acompañamos, con datos recogidos de forma ética y voluntaria. Documentar con rigor lo que observamos en la práctica naturopática es el primer paso para construir evidencia y abrir camino a investigaciones más amplias.
Mis perfiles: ORCID · Google Scholar · Zenodo · Academia
- Enfermedades genéticas, Enfermedades raras, Preprint, TEA
Background: it has been proposed that the hepatic glycolytic blockade associated with a hemizygous PFKFB1 variant (p.Ser159Thr) causes cytosolic NADH accumulation, with a secondary increase in demand on the malate-aspartate shuttle (MAS) — the principal mechanism for transferring reducing equivalents from the cytosol to the mitochondria in the hepatocyte. In the index case (companion report […]
- Preprint, TEA
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by high aetiological and clinical heterogeneity. In recent years, the need to investigate integrative approaches that account for its possible multisystemic nature has been increasingly recognised. From a complex systems perspective, effective interventions should be necessarily multidimensional and adaptive. Case presentation: A 3-year-old male participant […]
- Preprint, TEA
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by marked etiological and clinical heterogeneity. In recent years, there has been growing recognition of the need to investigate integrative approaches that consider its potential multisystem nature. From the perspective of complex systems theory, effective interventions should necessarily be multidimensional and adaptive. Case Presentation: An […]
- Preprint, TEA
Introduction: Mothers of children with autism spectrum disorder (ASD) experience sustained functional impairment across multiple life domains, including sleep, autonomy, health, and social participation. Despite growing evidence on caregiver burden in ASD, the impact of child-directed interventions on maternal quality of life has not been systematically documented. This study explores perceived functional changes in primary […]
- Preprint, TEA
Introduction: Mothers of children with autism spectrum disorder (ASD) experience sustained functional impairment that simultaneously affects all areas of daily life. Available instruments for assessing this impact, designed within the clinical-psychological framework, capture internal states such as stress or anxiety but fail to measure the mother’s functional capacity to sustain her own life. Naturopathy, through […]
- Preprint, TDAH, TEA, TMM
The Katia Dolle Method (KDM) is a hierarchical clinical decision framework developed within clinical naturopathy for multisystemic intervention in neurodevelopmental disorders, with primary application in autism spectrum disorder (ASD). Developed over more than twenty-five years of intensive clinical practice and applied to a population exceeding 1,000 users across 32 countries, the KDM integrates principles from […]
- Preprint, TOC
Background: Refractory obsessive-compulsive disorder (OCD) represents a major clinical challenge. We describe the case of a 34-year-old male (F.R.C.) with severe OCD (baseline Y-BOCS = 24/40), childhood onset, eleven years of partial pharmacological response and documented hypersensitivity to multiple psychotropic drugs. The baseline qEEG (T0, 02/10/2025) was consistent with PANDAS with OCD comorbidity and emotional […]
- Enfermedades genéticas, Enfermedades raras, Preprint, TEA
Background: PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1) is a bifunctional enzyme regulating hepatic glycolytic flux. No OMIM disease entity is currently associated with PFKFB1 variants, and the clinical literature is virtually nonexistent. We describe the first prospective interventional case study in a participant carrying a hemizygous PFKFB1 variant (p.Ser159Thr, ChrX:54984780A>T). Case: A 14-year-old male with myoclonic epilepsy, a […]
- Preprint
This report presents a longitudinal single-case study of a child with autism spectrum disorder (ASD) undergoing a multimodal naturopathic intervention based on the Katia Dolle Method® (KDM). The intervention was designed within a complex systems framework, targeting interconnected biological factors including intestinal dysbiosis, food hypersensitivity, micronutrient imbalances, and heavy metal burden. The case involves a […]
- Preprint, TEA
This retrospective cross-sectional study evaluates the effectiveness of the Katia Dolle Method® in reducing the severity of Autism Spectrum Disorder (ASD) in 183 children. The analysis was based on pre- and post-intervention ATEC scores collected between 2017 and 2024. Results show a highly significant reduction in ATEC scores (mean reduction: 39.20 points; p < 0.001), […]
- Preprint, TEA
This case report describes an 8-year-old boy with autism spectrum disorder (ASD) and obsessive comorbidity who underwent a four-month personalized naturopathic intervention. The intervention simultaneously targeted multiple pathophysiological axes, including hypothalamic–pituitary–adrenal (HPA) axis regulation, sleep disturbances, cerebral blood perfusion, neuroinflammation, cognition, and mental and emotional regulation. Leer más
- Preprint, TEA
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by difficulties in communication, social interaction, and repetitive behaviors. Considering its multifactorial origin and multisystem involvement, this single-case report applies a complex naturopathic intervention—the Katia Dolle Method® (KDM)—integrating immunonutrition, targeted supplementation, parental coaching, structured neurostimulation, and periodic biological monitoring over 21 months. A 4-year-old girl diagnosed with moderate–severe […]